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  • Highlighting the molecular mechanism underlying pancreatic cancer development Peer-Reviewed Publication

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A research group led by Professor Akio Ebihara of Faculty of Applied Biological Science of Gifu University and research student Daiki Sugihara of Graduate School of Natural Science and Technology of Gifu University visualized the protein binding site of the (pro)renin receptor known to be involved in pancreatic cancer development using an artificial intelligence-based protein structure prediction program. They predicted the 3D shape of this receptor and revealed the presence of hand-shaped grooves, allowing for the binding of multiple proteins. This study provides the first 3D structural insight into the receptor binding and one-to-many interactions, underpinning the functional versatility of this receptor. These findings will increase our understanding of disease pathogenesis and aid us in exploring novel modalities to treat human diseases, including hypertension and cancer.

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